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Human BodySurprise 5/5Difficulty 4/5Reviewed on September 14, 2026

A mutation in the LRP5 gene can make bones extremely dense and difficult to break.

Why it is true

A mutation in the LRP5 gene can make bones extremely dense and hard to break. People with this mutation rarely suffer fractures, but they may also have hearing or vision problems due to nerve compression.

Source: Nature

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